Dr. H.T. Lee

Vice Chair of Laboratory Research

Research Description

Dr. Lee's research focuses on the pathomechanisms of perioperative acute kidney injury and translational approaches to attenuate this injury. The laboratory is focusing on the role of ischemic preconditioning, adenosine receptors, sphingosine products, volatile anesthetics and local anesthetics in attenuating acute kidney injury in vivo as well as in vitro. The models used to induce acute kidney injury in vivo include renal ischemia reperfusion, cecal ligation and puncture induced sepsis and myoglobinuria rabdomyolysis model. Recently, a model of acute kidney injury in the setting of acute liver failure (hepatorenal syndrome) has been developed and multiple treatment modalities to treat this critical syndrome are being investigated. Dr. Lee uses multiple molecular and biochemical approaches as well as in vivo techniques to better understand both the injurious and protective signaling pathways involved in the injury.

For more information, please contact Dr. Lee at tl128@cumc.columbia.edu

Select Publications

View a complete list of Dr. Lee's publications.