Department of Anesthesiology Journal Articles

The department of anesthesiology is proud to present its scholarly achievements of our faculty. For each project, our research teams invest thousands of hours in applying for funds, planning, communication, observation, data collection, decision making, analysis, recording, and manuscript preparation. This often is followed by a wait of many months as submissions flow through the peer review process.  The research enterprise requires enormous focus and diligence, but the insight it yields allows us to respond to the needs of our patients.   Below is a list of the scholarly achievements of our faculty, each with a short summary and a link to the PubMed text. 

 

Perioperative neurocognitive disorder:  State of the preclinical science,” by Roderic G. Eckenhoff, Mervyn Maze, Zhoncong Xie, Deobrah J. Culley, Sarah J. Goodlin, Zhiyi Zuo, Huafeng Wei, Robert A. Whittington, Niccolo Terrando, Beverley A. Orser, and Maryellen Fazen Eckenhoff, was published in Anesthesiology.   (Link to the full text:  Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, Wei H, Whittington RA, Terrando N, Orser BA, Eckenhoff MF. Perioperative Neurocognitive Disorder: State of the Preclinical Science. Anesthesiology. 2020;132(1):55-68. )

The authors summarize some of the experimental methods that have been applied in preclinical postoperative cognitive dysfunction research, outline the knowledge that has been collected thus far, and expose possibilities for further exploration. The authors’ goal is to improve the quality and reproducibility of research in postoperative cognitive dysfunction and perioperative neurocognitive disorder.  They conclude by framing guidelines for optimal design, administration, and reporting for rodent studies in this area.

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A novel Tmem119-tdTomato reporter mouse model for studying microglia in the central nervous system,” by Chunsheng Ruan, Linlin Sun, Alexandra Kroshilina, Lien Beckers, Philip DeJager, Elizabeth M. Bradshaw, Samuel A. Hasson, Guang Yang, and Wassim Elyaman, was published in Brain, Behavior, and Immunity.

Using CRISPR/Cas9 technology, the authors generated a novel microglia-specific reporter mouse strain to study the role of microglia in health and disease.  The model allows the study of microglia phenotype in vivo and may be crossed with other reporter mice to analyze the relationship between microglia and other central nervous system or infiltrated cells.  It may also be useful for studying differences between male and female microglia. 

 

 

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“Quantitative ultrasound detects smooth muscle activity at the cervical internal os in vitro,” by Andrew P. Santoso, Joy Y. Vink, George Gallos, Helen Feltovich, and Timothy J. Hall, was published in Ultrasound in Medicine and Biology.

 

The authors investigate correlations between cervical smooth muscle cell force generation and a quantitative ultrasound parameter directly related to the acoustic impedance distribution, the effective scatterer diameter (ESD).  After administration of oxytocin, the authors noted significant positive correlations between muscle force generation and the ESD; thus, the ESD may be a potential biomarker for structure/function studies of cervical smooth muscle in vivo. 

 

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“Development of a risk score to predict postoperative delirium in hip fracture patients,” by Eun Mi Kim, Guohua Li, and Minjae Kim, was published in Anesthesia and Analgesia.

 

In this study, the authors developed and internally validated a prediction model of nine preoperative factors that may be used by perioperative physicians to assess the risk of postoperative delirium, specifically in hip fracture patients over 60 years of age. 

 

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“Comparison of carbon dioxide absorption rates in gynecologic laparoscopy with a valveless versus standard insufflation system: Randomized controlled trial,” by Obianuju S. Madueke-Laveaux, Arnold Advincula, Cara L. Grimes, Ryan Walters, Jin Hee Kim, Khara Simpson, Mireille Truong, Constance Young, Ruth Landau, and Timothy Ryntz, was published in the Journal of Minimally Invasive Gynecology. 

 

The authors compared CO2 absorption rates in 132 patients undergoing laparascopic surgery with valveless or standardized insufflation systems at intra-abdominal pressures (IAP) of 10 or 15 mm Hg.  They saw no differences in absorption rates based on system type or IAP.  Secondary objectives assessed differences in system type and pressures on anesthesiologists’ ability to maintain adequate end-tidal CO2, on patient reports of postoperative shoulder pain, and on surgeons’ visualization of the operative field.

 

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“International multicentre review of perioperative management and outcome for 

catecholamine-producing tumours,” by H. Groeben, M.K.Walz, B.J. Nottebaum, P.F. Alesina, 

Andrew Greenwald, R. Schumann, M.W. Hollman, L. Schwarte, M. Behrends, T. Rossel, C. Groeben, M. Schaefer, A. Lowery, N. Hirata, M. Yamakage, J.A. Miller, T.J. Cherry, A. Nelson, C.C. Solorzano, B. Gigliotti, T.S.Wang, J.K.G. Wietasch, P. Friederich, B. Sheppard, P.H. Graham, T.N. Weingarten, J. Sprung, was published in the British Journal of Surgery. 

 

Management and outcome data were collected for 1860 patients who had surgery for pheochromocytoma or paraganglioma, which can be complicated by hemodynamic instability during and after surgery.  Although complication rates are generally low, there was high variability in the perioperative management of catecholamine-producing tumors across the 21 centers reporting.  The authors conclude that international perioperative guidelines should be re-evaluated, and more studies are required to determine an optimal management approach. 

 

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“Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex,” by

Anthony H. Nguyen, Alex R. B. Thomsen, Thomas J. Cahill III, Rick Huang, Li-Yin Huang, 

Tara Marcink, Oliver B. Clarke, Søren Heissel, Ali Masoudi, Danya Ben-Hail, Fadi Samaan, Venkata P. Dandey, Yong Zi Tan, Chuan Hong, Jacob P. Mahoney, Sarah Triest, John Little IV, Xin Chen, Roger Sunahara, Jan Steyaert, Henrik Molina, Zhiheng Yu, Amedee des Georges, and Robert J. Lefkowitz, was published in Nature Structural and Molecular Biology. 

 

Images obtained with cryo-electron microscopy suggest that a single megaplex G-protein-coupled receptor (GPCR) can simultaneously activate G protein and bovine β-arrestin, providing a structural basis for sustained internalized G-protein signaling mediated by GPCR.

 

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“Mechanisms and therapeutic targets of ischemic acute kidney injury,” by Sang Jun Han and

H. Thomas Lee, was published in Kidney Research and Clinical Practice.

 

Renal ischemia and reperfusion initiate cascades of molecular and cellular events that lead to acute kidney injury (AKI). In this review, the authors summarize the mechanisms of ischemic AKI and identify possible therapeutic targets for prevention or treatment. They also suggest that the multiorgan dysfunction and inflammation that lead to high mortality in AKI could be a result of Paneth cell degranulation induced by ischemic AKI.

 

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“Health insurance and disparities in mortality among older survivors of critical illness:  A population study,” by Yoland F. Philpotts, Xiaoyue Ma, Michaela R. Anderson, May Hua, and Matthew R. Baldwin, was published in the Journal of the American Geriatrics Society.

The authors studied mortality in the first year after critical illness in patients age 65 and older.  Those receiving Medicaid benefits had higher mortality rates, especially among those discharged to skilled-care facilities (SCFs), compared to those with commercial insurance.  Disparities in care factors at SCFs should be studied to improve outcomes for older patients of low socioeconomic status. 

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“Diazepam and ethanol differently modulate neuronal activity in organotypic cortical cultures,” by Matthias Kreuzer, Paul S. Garcia, Verena Brucklacher-Waldert, Rebecca Claassen, Gerhard Schneider, Bernd Antkowiak, and Berthold Drexler, was published in BioMed Central Neuroscience.

 

In this study, the authors report that although diazepam and ethanol induce cortical network inhibition, diazepam modulates a distinct set of receptor targets, specifically GABAA receptors containing a γ-subunit, while ethanol acts on a variety of molecular targets.

 

Complete lists of department publications are available here for you to download. 

  1. Academic Year - 2019-2020
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  8. Academic Year - 2012-2013
  9. Academic Year - 2011-2012
  10. Academic Year - 2010-2011
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  12. Academic Year - 2008-2009